Fortunately, getting ear drops in your eyes is usually not serious. a defective dropper with fluid coming out as a "spurt" rather than the limited flow expected, detachment of the dropper nozzle, etc. Ifyou suspectyour dog is showing signs of vitamin D toxicity, take him or her to a veterinarian immediately. information is beneficial, we may combine your email and website usage information with I flushed it with warm water and he is acting normal, even giggled when getting water in his eye. In fact, up to 40% of U.S. adults are considered to have insufficient levels (not enough) of vitamin D, while around 6% are considered deficient in vitamin D. Worldwide, vitamin D deficiency affects around 1 billion people (1, 2, 3). Hills Pet Nutrition put out a press release about the recall. If you are still really worried, go to your GP. Help users support macular health and help provide support for AMD. This way, youll have less of a chance of grabbing the wrong bottle. Corticosteroid eye drops. It can be helpful to read the name of the medication out loud as you pick up the bottle before your dose. In February 2023, Nestl Purina PetCare Company recalled select lots of Purina Pro Plan Veterinary Diets EL Elemental (PPVD EL) prescription dry dog food after the company received two confirmed cases of a dog exhibiting signs of vitamin D toxicity after consuming the diet. However, taking too much vitamin D in the form of supplements can be harmful. TIA from a FTM who feels like crap. And temporary discomfort is the only symptom if treated properly. Vitamin D deficiency in children can have adverse health consequences, such as growth failure and rickets. The eye surgeon gave me a few days to use the antibiotic & steroid eye drops. Most often, these symptoms are temporary. https://www.microdemexsolutions.com. It can also occur if a dog accidentally gets into vitamin D supplements that a person in the household is taking. If you suspect that the pet food is the source of the excess vitamin D, we welcome case reports, especially those confirmed through diagnostics. Her vitamin D levels were discovered to be 265 ng/mL (11). These cookies allow the website to function, and allow its content to be optimised. For smaller children, Poison Control Centers recommend wrapping them in a towel and pouring water from a faucet or pitcher on the bridge of the nose (not directly in the eyes). You've got gut issues. Even though vitamin D toxicity isnt common, you may be at risk if you misuse over the counter vitamin D supplements, prescription vitamin D supplements, or injections. Mommy's Bliss. These drops are a nutrient solution, and supposedly increase the permeability of the tissues in the eye. 66cases of overdose were linked to a defect in the bottle, e.g. In another 2020 case report, a 56-year-old woman who took an average of 130,000 IU of vitamin D per day for 20 months in hopes of improving symptoms of multiple sclerosis was hospitalized for symptoms including nausea, vomiting, and muscle weakness. Also called. Here are 5 potential benefits of 5-HTP. This article explores the relationship between vitamin D and body. To provide you with the most relevant and helpful information, and understand which I imagine 3 would be the same in this case but you can always give your dr or poison control a call just in case. These cookies are used to optimise navigation, to measure site traffic, to offer videos online, and to allow subscribers to access the content they are entitled to as subscribers. Vitamin D3 in liquid form is best. Vitamin D deficiency. A number of factors influence a person's vitamin D levels. Vitamin D also regulates many other cellular functions in your body. So, there are more eye drop medications available. Hypercalcemia typically develops after people take megadoses of vitamin D for a prolonged period of time. This recall did not affect cat food, dry food (kibble), or treats. => Read Now. 2005-2023 Healthline Media a Red Ventures Company. The common causes of the dry eye syndrome include ageing, allergies and eye fatigue. "If your prescription drop is [to be used] only once a day, you have the entire day to put the rest of the . The most common treatment for mild dry eye is a type of eye drops called artificial tears. Dogs with excess vitamin D may vomit, have little appetite, drink and urinate more, drool excessively, and/or lose weight. Let the water rinse through the eyes and off the sides of the face. That's because your body can only absorb calcium, the primary component of bone, when vitamin D is present. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Read box instructions carefully 400 IU = 1 drop Put vitamin D up high or locked away from children. Vitamin D toxicity, where vitamin D can be harmful, usually happens if you take 40,000 IU per day for a couple of months or longer, or take a very large one-time dose. Debrox earwax removal aid. Mild irritation may occur but you should not need further medical intervention. Don't worry your LO is fine. This data is not used for advertising purposes. If you want to take vitamin D supplements, buy them from reputable manufacturers to reduce the risk of accidental overdose due to improper labeling. Taking vitamin D and aluminum-containing phosphate binders, which may be used to treat high serum phosphate levels in people with chronic kidney disease, might cause harmful levels of aluminum in people with kidney failure in the long term. Patient took eardrops from the top of a medication cart and instilled them in his eyes while the nurse was checking the electronic medication . CarePassTM. ConsumerMedSafety.org. The vitamin A eye drop has been used to effectively treat many eye problems including: Blurred vision. Studies have shown it to have antineoplastic properties; meaning, it fights cancer. Provide a full diet history to your veterinarian, including what food you (or other household members) give him and also other food or items he might have gotten into. First, call your local poison control center or the National Capital Poison Center at 1-800-222-1222. There is some evidence to suggest that vitamin D deficiency can help to relieve dry eye syndrome as a result of its anti-inflammatory properties. This includes separating where youre storing your drops and when youre using them. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. These symptoms had been present for almost 3 months and had . This is why insufficient or deficient levels of vitamin D may increase your risk of disease and infection, bone demineralization, and many other negative health outcomes (2, 3). Prescription eye drops have color-coordinated caps to designate what type of medication they contain. No Preservatives, No Sugar, Non-GMO, Allergy-Friendly, Culturelle, Baby Grow & Thrive Drops 0-12 Months, 0.3 Ounce, Ddrops Kids Booster 600IU 100 Drops - Daily Liquid Vitamin D for Kids. It took about 18 days for his calcium to return to expected levels (20). Color codes for topical ocular medications. Vitamin D is an essential nutrient that helps dogs regulate the balance and retention of calcium and phosphorus. Cases of vitamin D rodenticide or supplement poisoning are rapid onset showing signs of illness in a matter of hours or days. Registered in England and Wales. For this reason, many people need to take vitamin D supplements. Instead, its stored in fat tissue and the liver. Other side effects of vitamin D overdose are constipation and abdominal pain. Taking vitamin D can increase levels of calcium in the blood, and too much calcium can cause side effects. In a 2010 alert about vitamin D overdoses, FDA recommended that manufacturers standardize infant drops at 400 units per mL. Don't know if you can absorb ALL of what you took but as long as your vit D level goes up to a good level, not too low, not too high, that's what you want. is there anything to worry when nasal drops accidentally got For example, you may have an eye drop that should be taken at night. Its anti-inflammatory, antioxidant and neuroprotective properties support immune health, muscle function and brain cell activity. Expect some redness for a few hours and some itching with possible watering of the eyes and slight swelling of the eyelids. The patient far exceeded those dosages, however, and that led to extremely high levels of calcium in his blood. Some of the main symptoms of hypercalcemia include: However, not all people with hypercalcemia experience the exact same symptoms. Insufficient vitamin D is also connected to osteoporosis. Watch for signs of irritation but I doubt there will be. Separate administration timing of your medicated drops. I did the exact same thing to my LO and s, The saline drops just went into my LO eyes I put drops of water to try rinse out the eyes is that okay. Excess melanin, the protective pigment that gives skin its color, hinders the skin's ability to make vitamin D from sun exposure. vitamin d drops accidentally in eye vitamin d drops accidentally in eye ibew 353 collective agreement 2021 > chris reifert discogs > vitamin d drops accidentally in eye Posted at 16:45h in kit kat pride month: no straight lines by working with eir goddess That way, you force your brain to actively think about which bottle of drops youre using. the most helpful and trustworthy pregnancy and parenting information. Research shows that high dose maternal vitamin D supplementation (4000-6400 IU/d or a single monthly dosage of 150,000 IU) can enrich breastmilk adequately for infants. 1. What should I do if I think I have taken too much vitamin D? Check the label/google the brand - mine specifically says if you give two drops by mistake not to worry - just skip the next day. However, to avoid contamination, you shouldnt intentionally use the same saline drop bottle for both eyes and ears. If your bloodwork shows that youre low or deficient in vitamin D, your healthcare professional will recommend an appropriate daily dose to boost your levels. These included nausea, vomiting, muscle weakness, and kidney injury. 2018; doi:10.17925/USN.2018.14.1.41. It starts when the skin absorbs rays in the invisible ultraviolet B (UVB) part of the light spectrum. If you do not have any symptoms, you likely do not have hypercalcemia. To stay out of trouble, check all of your supplements and do the math; the amounts of vitamin D per serving are listed on the back of the bottle, right under "Supplement Facts." Taking high-dose vitamin D for too long: high-dose vitamin D such as 50,000 IU per week is sometimes . Accessed Dec. 6, 2020. The recommended daily amount of vitamin D is 400 international units (IU) for children up to age 12 months, 600 IU for people ages 1 to 70 years, and 800 IU for people over 70 years. And next time - read the instructions and if you aren't sure - ask the pharmacist to explain again. Always speak to your doctor before acting and in cases of emergency seek By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. Pazirandeh S, et al. In the 2020 case report mentioned earlier, the woman who took an average of 130,000 IU of vitamin D per day for 20 months was also hospitalized for symptoms related to hypercalcemia (11). Some researchers suggest that using topical vitamin D could be an even more effective mode of delivery for the prevention of dry eyes. I would also like to sign up for a free GoodRx account, Written by Jennifer Robertson, MD, MSEd, NBHWC. No better or worse. They immediately complain of burning and stinging. If yes, check to see if you have symptoms of toxicity (listed above); symptoms like feeling sick, feeling thirsty, constipation or diarrhea, poor appetite and feeling confused. ), we recommend that you accept all of these types of cookies. Vitamin D is extremely important for your overall health. information and will only use or disclose that information as set forth in our notice of Vitamin A eye drops have also been used in the treatment of many other conditions including: Sebaceous cysts. 4. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Here are 7 healthy foods that are high in vitamin D. Nutrient deficiencies may occur with almost every nutrient, but some are more likely than others. Vitamin D is important for optimal health, but 42% of Americans are deficient. Putting ear drops in your eye is a common mistake that can cause irritation and discomfort. For an explanation of the information and level of detail that would be helpful to include in a complaint to the FDA, please see How to Report a Pet Food Complaint. Healthcare professionals may recommend people who are very low in vitamin D take very high weekly doses of 50,000 IU for 8 weeks, followed by a maintenance dose of 2,000 IU per day after their levels reach 30 ng/mL (3). $21.23 reg $24.98. Prednisolone eye drops are used to treat short-term inflammatory eye conditions. If youre taking very high dose vitamin D supplements or are receiving vitamin D injections, your doctor will monitor your vitamin D levels to ensure they arent becoming potentially dangerous. The site is secure. Support Strong Bones & Immune System in Children. I wouldn't freak out about it - it's unlikely to have done a lot of harm as long as you have stopped now. Immunity Booster - Vitamin D Drops for Adults, Children, Kids and Infants. Try our Symptom Checker Got any other symptoms? He remained agitated and confused for the first 10 days of his stay in the hospital, but his symptoms gradually improved as his calcium levels dropped. A team of Toronto physicians reported on the case of a 54-year-old man who developed kidney damage after taking extremely high doses of vitamin D. It's a cautionary tale for consumers, medical experts say. Vitamin D supplementation is warranted for prevention of rickets. 1997-2023 BabyCenter, LLC, a Ziff Davis company. All rights reserved. explain your mistake and ask if they think you should have your vit D level checked. This is to remind you where the drops are to be used. Cookies from Google Analytics are used to generate anonymous statistics, in order to measure the website's traffic, and to optimise the site's usability, organisation and content. . There are four fat-soluble vitamins in the human diet: A, D, E, and K. This guide examines their health benefits, functions, and main dietary sources. However, you can still find products that hold 400 units in just a single drop! This article discusses 6 symptoms and side effects related to vitamin D toxicity. You will be redirected once the validation is complete. Overview of vitamin D. https://www.uptodate.com/contents/search. I'd rinse the plain water out with saline drops do the water doesn't irritate his eye. Vitamin D plays an important role in maintaining health. You'd be surprised how many people accidentally put ear drops in their eyes instead of their ears. (2021). Keep your eyes closed. Also has a trace of minerals such as Magnesium, Zinc, and Selenium. If you don't get enough vitamin D through sunlight or dietary sources, you might need vitamin D supplements. appropriate medical assistance immediately. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Saline drops would be a potential alternative to stronger ear medications like carbamide peroxide (Debrox). Children age 9 years and older, adults, and pregnant and breastfeeding women who take more than 4,000 IU a day of vitamin D might experience: There is a problem with There are numerous benefits of vitamin D for vision health. include protected health information. If so, you may have hypercalcemia and need medical attention. The main side effects of excessive vitamin D levels are related to excessive calcium in the blood (13). This involves adjusting the pH (acidity) and tonicity (concentration of salt) of the liquid. The vitamin d council actually recommends 1000ui per day for babies under 25 lbs. Wellbaby multi vitamin drops contains 30ml per bottle enough for 30 days at the recommended of 05ml taken twice daily . Its also helpful if you save the food in its original package, in case its needed for testing. In 70 cases, eye exposure to vitamin D was accidental, resulting from mishandling during oral administration. jackson jeffcoat salary winnipeg However, vitamin D toxicity is more common in people with certain medical conditions. You can get vitamin D intoxication if you take a very large dose for a prolonged period of time, or a huge dose for a short period of time. These include (5): Although uncommon, vitamin D toxicity can occur, especially in cases of: Vitamin D toxicity goes by a few other names, including hypervitaminosis D and vitamin D intoxication. or with $35+ orders. However, its important to avoid taking high dose vitamin D supplements, except with the guidance of a healthcare professional. Vitamin D intoxication involves some specific and nonspecific symptoms: Confusion. US Neurology. Eardrops were dispensed as eye drops following cataract surgery. Serotonin-producing 5-HTP supplements have become increasingly popular for their variety of health benefits. Vitamins D and K are crucial for your health, but some say vitamin D is harmful to those low in vitamin K. Here's a look at the science behind this, Vitamin D is an important nutrient that may also have benefits for weight loss. VDD is associated with an increased risk of common chronic diseases such as bone metabolic disorders, tumors, cardiovascular diseases, and diabetes. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Gold J, et al. Subscribersonly. vitamin d drops accidentally in eye. D-drops in eye :(: I feel like an awesome mum right now. Posted on 1 second ago; June 24, 2022 . This content does not have an English version. This is a detailed article about vitamin D and its health effects. AFrench poison control centre analysed 1255calls received between January 2017 and April 2020, concerning proprietary medicines (ZymaD and Adrigyl) based on vitaminD alone and designed for use in infants. Review/update the Vision Support + by Nuzena. These symptoms resolved after the child stopped taking the supplements (19). Medicated drops should also be stored in a different location than non-medical drop bottles, such as Superglue. Errors and accidents are frequent with vitamin D supplied in dropper bottles. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. I'd rinse the plain water out with saline drops do the water doesn't irritate his eye. a Target Plus partner. My contact solution is saline, but has other additives and that goes in my eye. When you visit the Prescrire website, cookies are stored on your web browser. . All rights reserved. Here's how to rinse it. SOURCES: Maria DeVita, M.D., chief, nephrology, Lenox Hill Hospital, New York City; Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Video: Why You Need Zinc and Where to Find It. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. And OTC eye drops tend to have white caps. People with vitamin D toxicityinduced hypercalcemia commonly have symptoms like confusion, depression, and psychosis. new york post sports editor; the 1931 report from this commission helped to institute; shooting in riverview, fl today; fairfield hills newtown ct trails; vitamin d drops accidentally in eye. Last medically reviewed on December 15, 2021. In addition to the suggestions above, saline drops are appropriate for both the eyes and the ears. He of course moved and the drops got in his eye. Mayo Clinic does not endorse any of the third party products and services advertised. PLOS One. For submissions through the Safety Reporting Portal, when asked Who are you? please select, A private citizen/business submitting a voluntary report, on the selection screen in order to guide you through a veterinary submission. Ear drops are available as both over-the-counter (OTC) and prescription products. For example, in a 2020 case report, a 73-year-old man developed vitamin D toxicity after taking 10,000 IU of vitamin D per day for many years (10). You can use them for earwax removal and to remove foreign objects or irritants from your eyes. When you take large amounts of vitamin D, your liver produces too much of a chemical called 25(OH)D. When your 25(OH)D levels are too high, this can cause high levels of calcium to develop in your blood. According to the pediatricians, your baby should receive a maximum of 400 IU of vitamin D a day. Eye injuries: you put what in your eye? Accessed Dec. 11, 2020. health information, we will treat all of that information as protected health Hypercalcemia can be life threatening and requires immediate medical attention. In extreme cases, coma has been reported (5). Report as Inappropriate. "Although vitamin D toxicity is rare owing to a large therapeutic range, its widespread availability in various over-the-counter formulations may pose a substantial risk to uninformed patients," said study co-author Dr. Bourne Auguste. Several precautions can help you prevent mixing up ear drops and eye drops. People who have levels that fall between 2129 ng/mL are considered to have insufficient vitamin D levels (1). Wellements Organic Vitamin D Drops, 0.15 Fl Oz, Liquid Vitamin D3 Supplement for Infant, Baby & Toddler, 1 Drop a Day, No Artificial Colors or Unnecessary Preservatives. Used for. In order for vitamin D to reach toxic or dangerous levels in the body, it needs to exceed 100 nanograms (ng) per mL. So you use a drop or two and it acts on the eye, barely anything is absorbed into the blood, and barely anything makes its way down into your nose/mouth. Yet, aside from fatty fish, there are few foods rich in vitamin D. Whats more, most people dont get enough sun exposure to produce adequate vitamin D. So, deficiency is very common. Upgrade to Patient Pro Medical Professional? Vitamin D: Fact sheet for consumers. Reports to the FDA can be submitted through the Safety Reporting Portal or by calling your local FDA Consumer Complaint Coordinators. These can include ear infections, ear wax removal, and swimmers ear. The discomfort occurs because eye tissue is more sensitive than the ears. Hi, Accidentally one drop of saline nasal - FirstCry Parenting. But it usually only results in temporary discomfort. Varying amounts of vitamin D 3 are available within . Even though toxicity is unlikely if you keep your daily intake levels below 10,000 IU per day and avoid excessively high intakes of vitamin D supplements, experts recommend that people with typical vitamin D levels do not exceed 4,000 IU of vitamin D per day (12). For example, a 2015 case study reported that an older man with dementia who received 50,000 IU of vitamin D daily for 6 months was repeatedly hospitalized with symptoms related to high calcium levels (16). Ships Free With. However, medicated ear drops dont always have these characteristics. information highlighted below and resubmit the form. Avoid taking high dose vitamin D supplements unless your healthcare professional recommends them. Please enable JavaScript on your browser and try again. Sunscreen, while important to prevent skin cancer, also can decrease vitamin D production. Stop using the medication and call your doctor at once if your child has a serious side effect such as warmth, redness, oozing, or severe irritation . Vitamin D drops for infants: mistakes to avoid, Your change of address has been received and will be processed promptly but will not appear instantaneously. If your healthcare professional finds that you have a vitamin D deficiency or insufficient vitamin D levels, they will likely recommend a supplement or vitamin D injections. The service requires full cookie support in order to view this website. It's funny how rational thought flies out the window when you need it the most. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. The formula also contains a solid base of Vitamins A, C, D, and the B complex. Even if you follow a healthy diet, you may require supplements to achieve optimal blood levels. I felt that this might help nutrients and other substances enter the eye and help the situation. Saline is much better in his eye than water!!!!! $15.49. Drops may interact to cause burning and watery eyes, which reduces their effectiveness. Eye drops and ear drops often come in similar-looking bottles. You should also do this because bacteria can begin to contaminate the medication. In 20cases, vitaminD was administered orally in place of products supplied in bottles with a similar appearance. This content does not have an Arabic version. The patient was then referred to a kidney specialist and underwent further testing. Have you taken more than 300,000 IU in the past 24 hours OR have you been takingmore than10,000 IU/day for the past three months or longer? Get prescription saving tips and more from GoodRx Health. NOTE: Babies need vitamin D for strong bones and teeth. Toxicity symptoms have been reported at extremely high blood levels in cases where people took megadoses (very high doses) of vitamin D supplements for extended periods of time. Vitamin D is naturally synthesized by the skin upon contact with sunlight. 25 years of experience as doctor. Fat-soluble vitamins are stored in the body and include A, D, E, and K, while the water-soluble vitamins, C and B, are flushed from your body and need to be replaced daily. If you put ear drops in your eye, youll quickly know something is wrong. @briannarv, wow this is genius lol how have I never thought of it thank you! Thank you! Carlyle Visi-Gold Lutein and Zeaxanthin 40mg is a supplement that aids in eye health. Is Garcinia Cambogia Safe for Weight Loss? In the dry eye space, a December 2018 study in Cornea investigated . The Best Supplements for Healthy Digestion, How to Get the Protective Power of Vitamin K. He's a clinical fellow in home dialysis at Toronto General Hospital and the University of Toronto. Find answers & help on 'Hi, Accidentally one drop of saline nasal drops fall into my 2 months baby eyes. 100 This article explains some of the symptoms and causes of vitamin D deficiency, as well. Vitamin A & D, topical side effects. information submitted for this request. The after hours peds clinic is closed. WebMD does not provide medical advice, diagnosis or treatment. A single copy of these materials may be reprinted for noncommercial personal use only. He fussed for a moment and then seemed fine but now his eye looks red and irritated. Advertising revenue supports our not-for-profit mission. A veterinarian may also continue to monitor blood calcium and phosphorus levels until they return to a healthy baseline. Burning and stinging occur immediately. Using saline drops could help lessen discomfort and risk of harm if a mix-up does occur. The symptoms of vitamin D toxicity are primarily related to hypercalcemia, which means excessively high blood calcium levels (13). Importantly, these symptoms occurred in response to extremely high doses of vitamin D3, which led to calcium levels greater than 12 mg/dL. By providing your email address, you agree to receive emails containing coupons, refill reminders and promotional messages from GoodRx. There is nothing on the Little Remedies' site about what to do if it gets in his eye. 1 | 10 | 20 | 30 | 40 | 50 | 60 | 70 | 80 | 90. This will help you avoid potential inappropriate or dangerous dosing. If you take large doses of vitamin D, you may experience stomach pain, loss of appetite . The Surprising Truth, Vitamin D Deficiency: Symptoms, Causes, and Treatments, 7 Nutritious Foods That Are High in Vitamin D, 7 Nutrient Deficiencies That Are Incredibly Common, Vitamin D 101 A Detailed Beginner's Guide, 5 Science-Based Benefits of 5-HTP (Plus Dosage and Side Effects), misuse of high-dose vitamin D supplements, digestive distress, such as vomiting, nausea, constipation, and stomach pain, fatigue, dizziness, hallucinations, and confusion, kidney stones, kidney injury, and even kidney failure, high blood pressure and heart abnormalities. Cookies from the Vimeo video platform are also essential for users to access video content online on the site, and for Prescrire to anonymously measure traffic for its videos. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our. Wash your hands. And to OD on a vitamin I would think it would have to be for months. If you get ear drops in your eyes, you should rinse them for 15 to 20 minutes with room temperature water and blink often. If you buy through links on this page, we may earn a small commission Heres our process. 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exerct distinct effects on human skeletal muscle function and gene expression. Vitamin D toxicity can cause symptoms like confusion, agitation, and unresponsiveness.