When skin cell retinoid receptors are bound with retinoids, a cascade of mechanisms that benefit skin complexion are switched on. These derivatives are metabolized to the active form by skin cells. Granactive Retinoid (now referred to as ‘the novel retinoid’) helps renew skin plumpness, elasticity and hydration to provide a radiant and fresh appearance. a) A 2% concentration of Granactive Retinoid which is a complex of solubilized Hydroxypinacolone Retinoate (HPR). This is achieved because retinoids increase the rate of skin turnover, while also reducing the rate of collagen breakdown, leading to plumper, younger looking skin. GRANACTIVE RETINOID ADVANCES OPPORTUNITIES IN VITAMIN A SKIN CARE. There is a bit of skin pilling everyday but it’s minor, manageable, non-invasive and satisfying quite frankly. Granactive Retinoid, an active technology from Grant Industries, is a solubilized system of Hydroxypinacolone Retinoate, a highly … GRANACTIVE RETINOID ADVANCES OPPORTUNITIES IN VITAMIN A SKIN CARE Addressing these issues without adversely affecting efficacy provides a breakthrough in opportunities with vitamin A in cosmetic formulations. Moreover, the novel retinoid stimulates skin cell proliferation; restoring thickness to skin that has become thinner over time. However, the novel retinoid was found to have 10 times better oxidative stability than retinol in DMI in thermal stress testing (see Thermal stress stability testing of Granactive Retinoid vs Retinol in dimethyl isosorbide). Retinoic acid is a topically applied ingredient recognized for its anti-ageing benefits; however, it can be irritating to skin and is sold as a prescription medication. The novel retinoid is intended to support anti-aging and anti-acne beauty treatments by providing low irritating, effective active delivery in daily maintenance applications. These derivatives are metabolized to the active form by skin cells. Granactive Retinoid, an active technology from Grant Industries, is a solubilized system of Hydroxypinacolone Retinoate, a highly-advanced form of retinoid which is, in fact, a non-prescription ester of all-trans direct retinoic acid that offers a multi-fold better effect against signs of aging than retinol, retinyl palmitate and nearly all other forms of non-prescription retinoid. This water-free solution contains a 5% concentration of an advanced retinoid active complex called Granactive Retinoid that has been shown to offer better results against multiple signs of aging than retinol without any of the irritation and drawbacks common with retinol. Dark spots and skin imperfections are reduced for a more even skin tone as a result of the retinoid’s promotion of skin cell-sloughing and a slowing effect on melanin production, which gives a brighter and more luminous appearance to skin. Granactive Retinoid (now referred to as ‘the novel retinoid’) helps renew skin plumpness, elasticity and hydration to provide a radiant and fresh appearance. Reduction of lines and wrinkles after 14-day Granactive Retinoid application, Figure 2. I’ve been seeing a lot of people say that it’s impossible to see results from retinoids (vitamin A derivatives used in skincare, like retinol, tretinoin, adapalene, tazarotene) for a certain amount of time. I've been using it nightly for 4 months now and honestly I can't say I really see a difference. hydroxypinacolone retinoate in dimethyl isosorbide (DMI). This time varies: some people say 2 months, or 3 months, or 6 months. S Mukherjee, A Date and V Patravale, Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety, Clin Interv Aging 1(4) 327-48 (2006). The novel retinoid is unique in that it processes innate retinoic activity, binding directly with retinoid receptors without the need for metabolic breakdown to more biologically active forms. When a product claims 2% Granactive Retinoid, it means 0.2% Hydroxypinacolone Retinoate (and 1.8% dimethyl isosorbide) on the ingredient list. All rights reserved. Note: When pregnant or breastfeeding, it is recommended to avoid any skincare products containing retinoids such as formulations with Granactive Retinoid or Retinol. This skin care active ingredient belongs to a class of chemical compounds called retinoids, which are natural and synthetic derivatives of vitamin A, capable of binding to retinoid receptors. Granactive Retinoid is a next-generation anti-aging product, delivering the performance of retinol and retinoid derivatives with significantly lower irritation potential, thus supporting clear, visibly more youthful looking skin with better consumer acceptance. Has anyone actually seen positive results with the granactive? Discussion/Conclusion: Retinoid compounds are known to be susceptible to decomposition by light and air oxidation. I chose it because it is listed as high strength, but with no to low irritation. Granactive Retinoid, an active technology from Grant Industries, is a solubilized system of Hydroxypinacolone Retinoate, a highly-advanced form of retinoid which is, in fact, a non-prescription ester of all-trans direct retinoic acid that offers a multi-fold better effect against signs of aging than retinol, retinyl palmitate and nearly all other forms of non-prescription retinoid. CHALLENGES WITH OLDER GENERATION VITAMIN A CHEMISTRIES. The novel retinoid is highly recommended for promoting clear skin when used in conjunction with monographed anti-acne treatments. 1-201-791-6700. Granactive Retinoid is Hydroxypinacolone Retinoate, a cosmetic grade ester of all-trans retinoic acid. Reduction in pore size is observed, leading to an overall increase in skin clarity. The binding of retinoid receptors can enhance gene expression, which effectively turns key cellular functions on and off. This is an ideal progression from the above 2 percent option if you want to take it up a notch. Retinol (>95%, Sigma‐Aldrich) was dissolved in DMI. Questions? As with all retinoids, this product should only be applied at night and used in conjunction with sunscreen to prevent extra … This cosmetic ingredient promotes cell turnover and renewal, which translates to improved skin clarity and the appearance of a healthier complexion. Contact us at: customerservice@cosmeticsandtoiletries.com Assessment of Skin Irritation Potential of Granactive Retinoid and Retinol Palmitate in a Reconstructed Human Epidermal Model Report No. Full ingredients list Privacy Policy Legal Terms The novel retinoid is dermatologically tested to offer less irritation potential than retinol, providing a gentle, safe and effective anti-aging retinoid (see Figure 2 and Table 1). The two primary reasons the use of retinoids is not universal are issues surrounding irritation potential and stability. You can’t go back in time, but Medica Labs will continue to develop products that work with your skin to correct the signs of aging. Medica Labs uses scientifically proven ingredients to formulate advanced skin care products. It is apparent from the HPLC data that under similar conditions that the retinol is highly unstable. The mechanism of action of Granactive Retinoid is advanced compared to retinol derivatives. 625SI.1 - January 15, 2014 3. So when you see a percentage of granactive retinoid being quoted, be aware that you need to divide by 10 to get the actual concentration of HPR. To minimize the effects due to light and air oxidation, the products were stored in low actinic glassware and under nitrogen atmosphere. BIOLOGICAL PATHWAYS TO YOUTHFUL SKIN WITH GRANACTIVE RETINOID. and were stored in low actinic glass bottles under a blanket of nitrogen gas. Subscribe, Visit the website Our science is complex, but the results are simple. These processes help fill in lines and wrinkles to give a youthful appearance, while safeguarding skin from further wrinkle development. The same process improves overall skin clarity, and appearance is enhanced for a healthier complexion. are recommend to help protect the novel retinoid in the formula. It is listed as an approved existing ingredient on China’s 2014 IECIC list. Instead in recent years, milder synthetic and natural derivatives have become popular alternatives to Retinoic acid. As a result, conventional antioxidants such as vitamin E, BHT, BHA etc. … Stimulating cell proliferation and cell turnover are important for normalizing cell renewal and repair processes. You may want to try the Granactive Retinoid in Squalan or Retinol in Squalan when you place your next TO order. I'm thinking of switching to their non granactive retinol line. To interact with retinoid receptors, retinol must first be metabolized to more active forms, such as retinaldehyde and retinoic acid using several enzymatic steps. Ingredients are the star of this not-so-ordinary show so you … The Ordinary Granactive Retinoid 5% in Squalane, 1 oz (or 30 mil as the rest of the world says) for $13.90. Granactive Retinoid is dermatologically tested to offer less irritation potential than retinol, providing a gentle, safe and effective anti-aging retinoid. The novel retinoid is a next-generation anti-aging product, delivering the performance of retinol and retinoid derivatives with significantly lower irritation potential, thus supporting clear, visibly more youthful looking skin with better consumer acceptance. The novel retinoid delivers high performance compared to retinol derivatives, but with a significantly lower irritation potential. Like all retinoids, the highly specific set of conjugated double bonds are susceptible to oxidation resulting in degradation. This can result in enhanced cell proliferation, biosynthesis of extracellular proteins and glycans, and improved cellular turnover. Stimulating cell proliferation and cell turnover are important for normalizing cell renewal and repair processes. This can result in enhanced cell proliferation, biosynthesis of extracellular proteins and glycans, and improved cellular turnover. Granactive Retinoid is highly recommended for promoting clear skin when used in conjunction with monographed anti-acne treatments. When skin cell retinoid receptors are bound with retinoids, a cascade of mechanisms that benefit the skin complexion are switched on. As humans age, skin becomes thinner and less elastic, leading to skin with a loose, sagging, and wrinkled appearance. Both samples were prepared to a working stock concentration of 0.1% wt. The Ordinary Granactive Retinoid 2% in Squalane is a great contender for newbies, too, plus it's super affordable. Acne-prone skin may experience a temporary increase in acne during the first few weeks of using any form of retinoid including those used in this formulation. It is a delivery system for the active ingredient hydroxypinacolone retinoate (HPR), which is a retinoic acid ester. Retinoids are known to have positive effect on aged skin.1 The novel retinoid combats the appearance of fine lines and wrinkles for a younger appearance while increasing skin elasticity for firmer, smoother skin texture. The effectiveness of the novel retinoid at filling lines and wrinkles can be seen in Figure 1. Results So Far : I am thrilled with the results from this Retinol. The Power of Retinol Without the Irratation. Log out Granactive Retinoid shows up to 10x more stability than retinol in DMI especially when comparing the 50% residual content. These results add credence to the beneficial safety and irritation profile of Granactive Retinoid as a topical cosmetic. My Account The manufacturer produces it as 10% active and 90% solvent called dimethyl isosorbide. What exactly is Granactive Retinoid? Granactive Retinoid offers formulators the ability to harness the powerful anti-aging properties of retinoid without irritation and stability issues traditionally associated with older generations of vitamin A analogues. Miscellaneous. The Ordinary Granactive Retinoid 2% Emulsion The Ordinary THE ORDINARY A game changer from day one, The Ordinary is the stripped back premium skin care brand without the eye-watering price tag. What it’s in: The Ordinary Granactive Retinoid 2% Emulsion. Retinoids are widely regarded as being among the most powerful (if not the most powerful) and effective anti-aging active compounds available. Test samples were 0.5% retinoid in Granactive DMI (INCI: Dimethyl Isosorbide). a) A 2% concentration of Granactive Retinoid which is a complex of solubilized Hydroxypinacolone Retinoate (HPR). This skin care active ingredient belongs to a class of chemical compounds termed retinoids, which are natural and synthetic derivatives of Vitamin A capable of binding to retinoid receptors. The Ordinary’s extended portfolio of retinoids includes the following formulations: Granactive Retinoid 2% Emulsion (Moderate Strength, No Irritation) Granactive Retinoid 2% in Squalane (Moderate Strength, No Irritation) Granactive Retinoid 5% in Squalane (High Strength, No to Low Irritation) Retinol 0.2% in Squalane (Low Strength, Moderate Irritation) Retinol 0.5% in Squalane (Moderate Strength, High … The Granactive Retinoid 2% in Squalane is a light-weight solution and absorbs into the skin efficiently, allowing for multiple serums to be applied in your regimen. The Ordinary Granactive Retinoid 2% Emulsion Garden of Wisdom Granactive Retinoid 5% Serum Be Minimalist Granactive Retinoid 2% (Emulsion) BFFECT Granactive Retinoid Emulsion 2% + Gaba The Ordinary Granactive Retinoid 2% In Squalane The Ordinary Granactive Retinoid 5% In Squalane Pacifica Clean Shot Granactive Retinoid 5% In Seawater This Works My … Experiment: Both samples were subjected to thermal stress stability testing. Retinoids don’t take as much time to reach that final product, so they’re more intense than retinol. Additionally, OTC retinols are often combined with other ingredients, such as moisturizing ingredients, to minimize dryness/irritation, add antioxidants, or brighten the skin. Retinol esters are often used to lower the irritation potential and increase stability, but a tradeoff is decreased retinoid activity and benefits. The low irritation profile of Granactive Retinoid versus retinol was demonstrated on a 24 hour occlusive patch test and can be seen in Image 2. Higher levels are possible without irritation, depending on the formula. Granactive Retinoid 5% in Squalane (High Strength, No to Low I… After a month, I’m already seeing a bigger difference in results than I had with the Granactive Retinoids or HPR Oils. The AHA Complex in Evening Detox is a trio of resurfacing Alpha Hydroxy Acids to deeply clean pores, help to banish breakouts and boost radiance. Allured Business Media, 336 Gundersen Drive, Suite A, Carol Stream, IL, 60188 USA, Figure 1. Levin explains that while retinoids and retinol do exactly the same thing, it typically takes longer to see results from retinols compared to retinoids. The Granactive Retinoid 2% Emulsion is milky/creamy in … The Ordinary Granactive Retinoid; Overall Rating: Texture/Feel: Thin, watery texture: Application: Super easy to apply with the dropper: Drying Time: Dries in about 10 seconds: Smell: Virtually no smell: Short Term Results: Hydrated and soft skin: Long Term Results: Helps reduce the appearance of fine lines: Ingredients: Caprylic is used to help the skin retain moisture. Gia Mazur is a staff writer for the Lifestyles Department of The Times-Tribune. The samples were placed in a heated water bath at 50°C and shaken. © 2020 Allured Business Media. The 10% refers to the complex, which is granactive retinoid + the solvent dimethyl isosorbide in a 1:9 solution. The next-generation anti-aging formula with 2% Granactive Retinoid is dermatologically tested to offer less irritation & multi-fold better effect than other retinol and retinoid derivatives Boosts cell turnover & stimulates collagen production to erase fine lines and wrinkles, revealing radiant glowy skin granactive retinoid. Irritation profile with a. Granactive Retinoid vs b. retinol, Thermal stress stability testing of Granactive Retinoid vs. Retinol in dimethyl isosorbide, Table 1. This cosmetic ingredient promotes cell turnover and renewal, which translates to improved skin clarity and the appearance of a healthier complexion. Both compounds show signs of decomposition by being stored under atypical conditions. The novel retinoid should be added to the oil phase of all emulsion types, with a clinical use level of 1-2%. Retinoic acid, also known as tretinoin or Retin-A, is the active form of vitamin A, which binds directly to the skin cells' retinoid receptors. [misc] Anyone have visible results with TO granactive retinoid? Sample preparation: Granactive Retinoid is 10% wt. The effectiveness of Granactive Retinoid at filling lines and wrinkles can be seen in Image 1. This water-free solution contains a 5% concentration of an advanced retinoid active complex called Granactive Retinoid that has been shown to offer better results against multiple signs of aging than retinol without any of the irritation and drawbacks common with retinol. Retinol (vitamin A) is the most popular topical retinoid used to date, but its skin irritancy and instability to sunlight has limited its scope and appeal. For anti-acne claims, the retinoid must be co-formulated with an approved anti-acne active as subject to regional legislation. To “unsubscribe,” click the link at the bottom of any e-mail we send. Due to its superior irritation and stability profile, Granactive Retinoid allows new and exciting opportunities with vitamin A, one of the most trusted efficacious anti-aging active ingredients. Since HPR binds directly to retinoid receptors, its activity is similar to pure retinoic acid. Although the benefits of retinoids have been known for decades, skin irritation, photochemical instability, and toxicity concerns have hindered their use. Squalane also has the added benefit of being an exceptional hydrator. Bakuchiol: International journal of cosmetic science 36 (3) DOI: 10.1111/ics.12117 Source: PubMed January 2014 To interact with retinoid receptors, retinol must first be metabolized to more active forms, such as retinaldehyde and retinoic acid using several enzymatic steps. ‘Granactive Retinoid’ is a next-generation retinoid active technology, which can not only achieve better anti-ageing results than traditional retinol but do so without the irritation commonly associated with it (it often causes redness and flaking). So your skin prefers retinoids to acids, that's an important discovery! A gentle, effective anti-aging serum. The retinoid compounds were subjected to accelerated degradation by thermal stress testing. Clinical results for Granactive Retinoid, Thermal stress stability testing of Granactive Retinoid vs Retinol in dimethyl isosorbide, customerservice@cosmeticsandtoiletries.com, Local irritation and sensitisation potential assay, Skin irritation potential vs. retinol palmitate, Toleration under environmental stresses vs. retinol palmitate. This offers easy formulation into O/W emulsions, W/O emulsions and other formula types. Granactive Retinoid helps renew skin plumpness, elasticity, and hydration to provide a radiant and fresh appearance. As being among the most powerful ) and effective anti-aging retinoid safe and effective anti-aging active compounds.. Are not limited to ) skin care products: the trade name of HPR is Granactive retinoid at filling and! In skin clarity and the granactive retinoid results of a healthier complexion oil phase of Emulsion. Metabolized to the active form by skin cells % refers to the active form skin. 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The Ordinary Granactive retinoid ADVANCES opportunities in vitamin a skin care products under similar conditions that the retinol is recommended. Cell proliferation, biosynthesis of extracellular proteins and glycans, and toxicity concerns have hindered their use most! Of formulations and perfectly fits the granactive retinoid results trend towards milder products + the solvent dimethyl isosorbide ) synthetic and derivatives...