The drug also works to control nausea and vomiting due to the relationship between the eyes and vestibular system. Most veterinarians believe Cerenia injectable stings less if kept in the refrigerator. Can Cerenia be used with other medications? Dog Cerenia side effects include diarrhea, excessive drooling, drowsiness, bloody stools, lack of appetite, otitis or inflammation of the ear, endotoxic shock, hematuria, and excoriation. Placebo (n=106 ) Cerenia (n=107 ) # dogs. Cereniatablets should be stored at controlled room temperatures between 68-77F and brief exposure to temperatures 59-86F are acceptable. This is about 8 percent of researched dogs. Due to this effect on the brain, Cerenia is a potent drug that can treat and prevent vomiting from a wide variety of causes. Your email address will not be published. This may involve packing a special blanket or toy or rubbing a bit of aromatherapy oil on his paws for relaxation. However, its essential to consult with your veterinarian before giving your dog any new medication or supplements. In dogs, direct side effects from this medication are rare, but may . If you have concerns due to a longer, upcoming trip, ask your veterinarian what options you have to prevent motion sickness vomiting. Excessive drooling, diarrhea, vomiting, loss of appetite, and mild pain (from injection) are a few common side effects of Cerenia for dogs It is never fun when your dog vomits! Yes, there are several alternatives to Cerenia for treating nausea and vomiting in dogs. Cerenia should not be given to puppies under 16 weeks old or dogs that are pregnant or nursing . Your veterinarian may want to reevaluate your pet to see if a more serious underlying condition is present. Dogs allocated to the placebo group were treated using either an injectable placebo solution or placebo tablets once daily at the discretion of the clinician. If you suspect an overdose, immediately seek emergency veterinary care, or contact an animal poison control center. Interpretation of these study results is complicated by the health status of study animals. Watch for other signs of illness in your pet and changes in appearance or behavior. Cerenia has been studied in over 200 dogs, both young and old, with no evidence of increased susceptibility or side effects in geriatric animals. Topical exposure to Cerenia (maropitant citrate) may elicit localized skin reactions in some individuals. The dosage and duration of treatment may need to be adjusted based on the puppys size and medical history. If your dog experiences these symptoms, its important to monitor them closely and contact your vet if they persist. No dogs were reported being euthanized though. Additionally, some dogs in the study tested positive for canine parvovirus, however, clinical parvoviral disease was not definitively diagnosed. Cerenia is fairly new drug that may be given as an injection or given by mouth to dogs who are suffering from nausea and vomiting. Its also important to follow the prescribed dose and avoid giving your dog too much or too little of the medication. Vomiting and nausea are common side effects of Cerenia in dogs and cats. What are the side effects of Cerenia? This appears to happen when Cerenia is preserved with a preservative known as metacresol. Do some investigating to determine the cause of the vomiting. Efficacy and safety of maropitant, a selective neurokinin 1 receptor antagonist, in two randomized clinical trials for prevention of vomiting due to motion sickness. This prevents nausea and vomiting. These concerns are not unfounded, considering that the drug information leaflet lists several potential side effects some of which can be quite scary. Despite its effectiveness, some pet owners . Cerenia peach-colored tablets are scored with a break line, and contain 16, 24, 60 or 160 mg of maropitant as maropitant citrate per tablet. Acute vomiting in dogs is more extreme and often requires the care of a veterinarian for effective treatment. If you notice any unusual behavior in your dog while theyre taking Cerenia, its important to let your vet know right away. When in the car, its most likely due to motion sickness. These symptoms may include hives, swelling of the facial area, and/or difficulty breathing. Home / Adverse Drug Reactions / Cerenia for Dogs Side Effects. If your dog is suffering from acute vomiting, it may not always happen indoors, which means you may not always be privy to it right away. What are the side effects of Cerenia in dogs? Uncommon side effects include: Allergic reaction Diarrhea Poor appetite Lethargy Uncoordinated walking Tremors Injectable Cerenia may cause pain and swelling at the injection site. Countless puppies love chewing walls and their corners. Pets love spending as much time with their owners as possible and vice-versa. Cerenia is a safe and effective drug for the treatment of vomiting in dogs. Side Effects for Cerenia in Dogs. Cuteness, 9 Feb. 2017, Accessed 17 Nov. 2017. Of the 199 dogs included in the analysis for effectiveness, 27 of 54 dogs (50%) in the placebo group displayed vomiting at some time during the study and 31 of 145 dogs (21.4%) in the treated group displayed vomiting during the study period. The same is true for pregnant or nursing dogs since it is not yet . It gives everyone a chance to get out of the car and get relief. In addition to these rare side effects, cats may also experience abnormal breathing, recumbency (laying down and unable to get up), vomiting, panting, and muscle tremors. If your pet has accidentally overdosed on Cerenia, side effects may be similar, including loss of appetite, bloody stool, and diarrhea. In studies, Cerenia has proven to be so effective, that even dogs who were given powerful emetics (substances known to cause vomiting) such as syrup of ipecac or apomorphine, failed to vomit courtesy of this drug. Denamarin for dogs is a supplement given to pets that need liver support. In most cases, Cerenia is given once a day, either with food or on an empty stomach. When a European field study tested dogs for adverse reactions from using Cerenia, 8 out of 107 dogs 8 developed drowsiness, lethargy or apathy. Cerenia works on average within one hour of administration. One dog in the 24 mg/kg/day group died of unknown causes on study day 2 and a dose dependent increase in occurrence and severity of bone marrow hypoplasia and lymphoid depletion was observed histologically. However, if it is almost time for your next dose, your veterinarian may instruct you to skip the missed dose and resume your normal dosing schedule. It has also been used in cats to treat fear and anxiety associated with . Another appetite stimulant is Cerenia (Maropitant Citrate), a common anti vomiting medication for both dogs and cats. PetMDs medications content was written and reviewed by veterinary professionals to answer your most common questions about how medications function, their side effects, and what species they are prescribed for. If it is the result of your dogs diet, discuss alternatives with your veterinarian to introduce or eliminate foods as needed. . Cerenia (maropitant citrate) is not approved for use in humans. , or simply because he ate something he shouldnt have. While side effects are uncommon, Cerenia for dogs can potentially cause: Vomiting Lethargy Drowsiness Muscle tremors Anorexia Diarrhea Loss of appetite Drooling Pain and swelling (at the injection site if injectable Cerenia is given) Consult your veterinarian if you think your dog may be experiencing any side effects of Cerenia. If youre introducing your pet to the medication for the first time, its wise to set out on a test drive before hitting the road for the real trip. According to a published study, oral maropitant is commonly used off label in cats at the same dose (1 mg/kg q24h), which differs from the labeled dose for dogs (2 mg/kg), probably due to the difference in . In case of accidental ingestion, seek medical advice. Like any drug, Cerenia can have side effects, so its crucial to monitor your dogs behavior and contact your vet if you notice anything unusual. It may act as a mild pain control medication. In some cases, prolonged use of Cerenia may lead to digestive issues, such as diarrhea or loss of appetite. www.cuteness.com/article/cerenia-dogs-side-effects. Cerenia's active ingredient helps block vomiting signals in your dog's . doi:10.1136/vetreco-2017-000262. If youre introducing your pet to the medication for the first time, its wise to set out on a test drive before hitting the road for the real trip. The concomitant use of Cerenia with other protein bound drugs has not been studied in dogs. In most cases, your veterinarian may instruct you to not give extra or double doses. Maropitant (Cerenia) is licensed for use in the USA and Europe for prevention of motion sickness and acute vomiting in situations such as chemotherapy for dogs 16 weeks of age (Sedlacek et al., 2008).It is recommended as a once-daily administration at 1 mg/kg SC or 2 mg/kg orally. Is Cerenia an appetite stimulant? . This is interesting because this is quite a large number and quite close to the number of dogs hypersalivation when receiving the actual drug. Cerenia is generally well tolerated by dogs, with few side effects. What are the side effects of cerenia in dogs? The risks for Cerenia side effects in dogs are increased when Cerenia is combined with other drugs such asphenobarbital(a medication to control seizures);chloramphenicol(an antibiotic);ketoconazolealong with some other antifungal drugs, certain types of thyroid hormone supplements, behavioral medications andsome cardiac drugs, and non-steroidal anti-inflammatory drugs. Most dogs will maintain a normal appetite while taking maropitant citrate, but a loss of appetite is a possible known side effect. This effect can be reduced by keeping the medication refrigerated. Cerenia requires a prescription from your veterinarian. In vivo model studies in dogs have shown that maropitant has antiemetic effectiveness against both central and peripheral emetogens including apomorphine, and syrup of ipecac. However, its important to administer Cerenia at least an hour before the motion sickness-inducing activity to ensure its effectiveness. How long do side effects of Cerenia last? Maropitant. If your dog shows any of these symptoms after taking Cerenia, contact your vet immediately. About 25% of all animals that receive the drug experience vomiting. As the name implies, activation of the vomiting center leads to vomiting. DeckersN, RuigrokCA, VerhoeveHP, etal. Three dogs given a placebo out of 195 also developed sedation and/or depression. Wash hands with soap and water after administering drug. A dose dependent increase in severity of bone marrow hypoplasia was observed histologically. Your veterinarian may recommend other antiemetic medications or dietary changes to alleviate your dogs symptoms. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Side effects can include hypersalivation (excessive drooling), nausea, vomiting, and diarrhea. Discover what type of coat the Havanese dog breed has and its main characteristics. Please note: Cerenia may interact with certain medications and medical conditions, including but not limited to . Its a powerful drug that works by blocking certain receptors in the brain and gastrointestinal tract. To make the trips enjoyable for all, find out what your dog needs to have a safe and comfortable ride. Always monitor your dogs behavior after administering Cerenia and contact your veterinarian if you notice any adverse reactions. What are the side effects of Cerenia for dogs? This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Dosage. US Patents: See US 6,222,038; US 6,255,320. In case of accidental eye exposure, flush with water for 15 minutes and seek medical attention. Forty Beagle dogs (20 males and 20 females) between 16 18 weeks of age were administered Cerenia Tablets orally once daily for 6 days at 0, 8 and 24 mg/kg. This appears to happen when Cerenia is preserved with a preservative known as metacresol. Cerenia does not target the stomach to decrease nausea. So, what are the side effects of Cerenia for dogs? Cerenia is not recommended for use in dogs less than 16 weeks old. Other Cerenia side effects in dogs include inflammation of the ear (3 dogs out of 206, 1.5 percent), endotoxic shock (2 dogs out of 206, 1 percent), blood in urine (2 dogs out of 206, 1 percent) excoriation, presence of erosion or ulceration caused by scratching, biting or rubbing ( 2 dogs out of 206, 1 percent). The more you get to know your pet and what he does or does not respond favorably to, the easier it becomes to provide the right kind of care to maintain his health over time. The rare side effects of Cerenia can include: Diarrhea. We have to warn you, Cerenia comes with common side effects, as does every other medication on the market today. This will help you determine if its an ongoing problem or a one-time event. Its designed to prevent vomiting and nausea in dogs. There are certain conditions your dog may grow out of as years go on and conversely, there are conditions that may affect him worse as he gets older. Generic name: maropitant citrate While Cerenia is often used to treat vomiting, it can sometimes cause diarrhea or vomiting as a side effect. Cerenia or maropitant citrate is an FDA-approved antiemetic medication used for treating acute vomiting in dogs and cats and motion sickness.. The vestibular system is found in the inner ear and is responsible for gathering information about balance and motion. Meggitt, Jane. Also, your pet may have a serious allergic reaction if hes never taken Cerenia before. He or she will determine if Cerenia is a good option for your pet or decide what alternatives there might be. Not all dogs are automatically good candidates for Cerenia. Conder GA, Sedlacek HS, Boucher JF, Clemence RG. Likewise, dogs with impaired liver function are at higher risk for these side effects. Cerenia is not recommended for use in dogs less than 16 weeks old. Placebo dogs though were also affected with 5 dogs developing bloody stools, ultimately comprising 7.2 percent of the 69 tested. Also, while its good to pack snacks and plenty of water for your pet, allocate these in the appropriate amounts. Cerenia may interact with certain drugs, including antibiotics and pain medications, so its important to disclose any medication your dog is taking to prevent any potential adverse reactions. Take your dog for a walk and let him get out his energy prior to traveling, especially if youre going to be on a long flight or on a tight schedule when driving. Youll want to make sure there is adequate assistance nearby. The duration of these symptoms depends on the individual dog, but many dogs will recover within 24 hours. This may include massage therapy, acupuncture, aromatherapy, or a change in diet and exercise. If you notice any of these side effects, contact your veterinarian. It could be symptomatic of a larger problem, which may create its own larger action plan of care. On the other hand, the study also mentions 4 dogs dying during the study out of 69, which is 5.8 percent when given a placebo. In people, topical exposure may elicit localized allergic skin reactions, and repeated or prolonged exposure may lead to skin sensitization. Information on how to report an adverse reaction can be found here: Reporting Animal Drugs. There were 8 dogs (4 males and 4 females) in the 2 mg/kg group and 16 dogs (8 males and 8 females) in all other groups. Finally, its possible for dogs to have an allergic reaction to Cerenia. Buy Our Products at Local Retailers & Veterinarians. According to the field study, 19 dogs out of 195 developed hypersalivation and that's 9.7 percent. 1-800-PetMeds explains the medication comes in four different sizes to accommodate dogs of all sizes, and it is a once daily medication that can be administered for up to five days. However, as with any medication, its essential to follow your veterinarians instructions carefully and monitor your dog for any adverse reactions. Even with doses exceeding the recommended dose, side effects are rare. However, long road trips, airplane travel, or other modes of transportation may cause your pet to get motion sickness, which then leads to vomiting. The medication needs a change to become fully absorbed and start working before your dog gets into a moving vehicle. But when dogs are sick, they generally like to be calm as there is a lack of energy. Hemp nutrition is one alternative pet owners are turning to as part of implementing an all-natural diet. There were no notable differences in mean laboratory values between Cerenia-treated and placebo-treated patients. Can Cerenia cause any long-term side effects in dogs? Please see full Cerenia Prescribing Information. Where the dogs treated ethically? As with any medication, its essential to consult your vet before giving Cerenia to a pregnant or nursing dog. Cerenia is designed to inhibit the processes in the brain that cause nausea and vomiting. While the drug is well tolerated in dogs, a higher dosage may cause side effects. Adverse reactions can also be filed directly with the FDA using their form. or stool, pain, and weakness. Maropitant and other antiemetics should not be used in patients suspected of toxin ingestion, as this may mask progression and allow more time for toxin absorption. Whether your dog develops side effects from the Cerenia may vary based on several factors. Finally, take as many breaks as you can. Swelling or pain at the injection site has been seen with the administration of the injectable form. If vomiting persists despite treatment, the case should be re-evaluated. By blocking it, Cerenia helps prevent these symptoms from occurring. Although tempting, its not recommended to hide it in food like hot dogs or cheese because it may affect the absorption and effectiveness rate. Some dogs may experience a decrease in appetite or refuse to eat altogether while taking this medication. ASPCA Animal Poison Control (888) 426-4435. However, its essential to give the medication time to work, and your dog may need to take Cerenia for several days to see the full benefits. The most common side effects are vomiting and hypersalivation at the higher doses required for motion sickness. Its not available for over-the-counter purchase. Following the initial dose, dogs allocated to the Cerenia group were treated with either Cerenia Tablets at a minimum of 2 mg/kg orally or Injectable Solution at 1 mg/kg subcutaneously once daily at the discretion of the clinician. www.cerenia.com/frequently-asked-questions.aspx. Cerenia is primarily used to control nausea and vomiting in cats, including motion sickness. One of the most common side effects of Cerenia is drowsiness or lethargy. To reduce the risk of these side effects occurring, dog owners should talk to their veterinarians about the correct dosage for their pets. You should monitor your pet carefully while they are receiving this medication to ensure they do not have any negative side effects from it. Maropitant citrate (brand name: Cerenia) is an antiemetic used to treat vomiting and motion sickness in dogs and cats. are good options when traveling because they dont affect other foods or medications you may be giving your dog. In the most severe case, dogs may act as though they are experiencing a burning sensation. Dogs may have experienced more than one of the observed adverse reactions. Fortunately, Cerenia helps prevent acute vomiting by blocking substance P (which triggers vomiting) in the brain. The medication is prescribed for use only once per day, typically to be administered before the actual start of the trip. Use with caution in dogs with hepatic dysfunction. Some dog owners report that their dog's stools may turn a bit on the mushy side when they are given Cerenia. However, this can be cured, though by getting the dog lots and lots water. Pain/vocalization upon injection is a common side effect. It's often forgotten though that the act vomiting, albeit distressing to endure or witness, plays the fundamental role of ridding the body from harmful substances such as toxins, viruses and bacteria. On top of diarrhea, some dogs also developed blood in their stools. If this is the first time your dog is taking the medication, its important to be extra aware of any changes in behavior or appearance. Tags: cerenia for dogs, cerenia for dogs side effects, cerenia injection for dogs side effects. Of course, not all dogs will develop this. With a degree in Animal Behaviour and over a decade of practical animal husbandry experience, Hannah's articles cover everything from pet care to wildlife conservation. Cerenia is given orally. Lets take a closer look. Motion sickness, a bad diet, or illness can cause vomiting. The absolute bioavailability of maropitant was much higher following SC injection (91% at 1 mg/kg) than after PO administration (24% at 2 mg/kg). What should I do if my pet continues to have acute vomiting? . When she isn't creating content for blog posts, Hannah enjoys long walks with her Rottweiler cross Senna, reading fantasy novels and breeding aquarium shrimp. Although Cerenia is claimed to benon-sedating (which makes it a better choice than Benadryl or Dramamine for car sickness) a few dogs may develop drowsiness as a side effect. Oral bioavailability may be underestimated due to the presence of nonlinear kinetics and the resulting longer T seen after intravenous (IV) administration. The chemical structure of maropitant citrate is: Cerenia (maropitant citrate) Tablets are indicated for the prevention of acute vomiting and the prevention of vomiting due to motion sickness in dogs. In addition to these rare side effects, cats may also experience abnormal breathing, recumbency (laying down and unable to get up), vomiting, panting, and muscle tremors. This can be a scary statistic for concerned dog owners. Even in reports of death from Cerenia in dogs,it is difficult to prove the cause of death unless the dog owners elects to have an autopsy done. " Some dogs may also experience loss of appetite, vomiting, or abdominal pain. ; Hypersalivation, drowsiness, lethargy, anorexia and diarrhea are possible side effects from Maropitant . Will my dog have to take Cerenia for the rest of his life? No. This means that roughly 3.9 percent were affected by the runs. Hypersalivation simply means that the dog's salivary glands produce excess saliva. The empirical formula is C32H40N2O C6H8O7 H2O and the molecular weight 678.81. The injectable formulation is FDA approved for use in both dogs and cats, but the tablets are only approved by the FDA for use in dogs at this time. What are the possible side effects of Cerenia? This supplement is often in veterinary medicine used for . This can be concerning, especially if your dog is already underweight or has a history of poor appetite. The only common side effect of Cerenia includes pain on injection, which resolves within seconds. It is a prescription drug, which means that it needs to be prescribed by a licensed veterinarian, so you'll hardly find it over the counter somewhere.. Cerenia works in a way that it blocks particular receptors that cause vomiting, thus effectively . If you or one of your travel companions also get motion sickness, talk to your doctor about potential remedies. Vomiting is a side effect of something else. But when at home, it could be indicative of a variety of things. All in all, Cerenia does have a range of side effects. Its possible your dog will always need to take medication for motion sickness. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If you notice any changes in your dogs behavior or health, contact your veterinarian immediately. If you notice any of these symptoms in your dog, seek immediate veterinary care. Each tablet is scored, allowing for easy and accurate dosing. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Enter your name and email to get exclusive offers and updates from Canna-Pet! This way you can monitor how well your dog is responding to the medication and if its a suitable option long-term. Some dogs may also experience loss of appetite, vomiting, or abdominal pain. Cerenia is also used to treat acute nausea and vomiting in dogs and can alleviate nausea associated with chemotherapy. Do some investigating to determine the cause of the vomiting. On top of this, your dog can be lethargic. How long does it take for Cerenia to work? It's more likely the stress that's causing it - a normal reaction in dogs to any kind of stress. Other Cerenia side effects in dogs include inflammation of the ear (3 dogs out of 206, 1.5 percent), endotoxic shock (2 dogs out of 206, 1 percent), blood in urine (2 dogs out of 206, 1 percent) excoriation, presence of erosion or ulceration caused by scratching, biting or rubbing (2 dogs out of 206, 1 percent). Where any steps take to reduce stress in dogs if housed in a laboratory? Repeated or prolonged exposure may lead to skin sensitization. One specific long term use is to prevent vomiting in cats with renal failure. In the U.S. field study, sedation or depression was found in 2 dogs out of 208 which means that roughly one percent were affected. Additionally, this medication only remains in the body for 24 hours, so side effects are typically short-lived. Anorexia (no appetite) Is drowsiness a side effect of Cerenia? Maropitant is the non-proprietary designation for a substituted quinuclidine. Each peach-colored oval tablet is scored and contains 16, 24, 60 or 160 mg of maropitant as maropitant citrate per tablet. These products are not intended to diagnose, treat, cure, or prevent any disease. If one of my dogs already uses Cerenia, can I give it to my other dog for motion sickness, too? For a copy of the Material Safety Data Sheet (MSDS) or to report adverse reactions call Pfizer Animal Health at 1-800-366-5288. Make sure your vet knows whether your dog is on other medications while taking Cerenia. Masking the symptoms leads to delayed diagnosis and treatment. Although hepatic first-pass metabolism contributed to the relatively low bioavailability after an oral dose, prandial status does not significantly affect the extent of oral bioavailability. According to veterinarian Dr. Jennifer Coates, giving Cerenia on a schedule of five days ontwo days off, or every other day, helps prevents this side effect. If motion sickness plagues your dog, then any extra, non-moving moments are most likely much appreciated. While the cerenia can help with nausea and vomiting from motion sickness, it can't help with the mental end of it. The side effects of Cerenia in dogs may be several. Cerenia Tablets administered at 40 mg/kg and 50 mg/kg caused clinically relevant signs of weight loss, vomiting, soft stools, weakness, lethargy, salivation and hypokalemia. Dont feed your dog up to one hour before giving him Cerenia and plan to give it to him approximately two hours before disembarking. Veterinary Record Open 2018;5:e000262. When given to dogs, Cerenia can cause vomiting. Product Description. When dogs were dosed for motion sickness, vomiting not related to motion sickness occurred in 11 dogs out of 208 (5.3 percent), muscle tremors occurred in 2 out of 208 dogs (1 percent), retching occurred in 1 out of 208 dogs (0.5 percent) and flatulence (intestinal gas) in 1 out of 208 dogs (0.5 percent). Cerenia FDA Prescribing Information, Side Effects and Uses. Drugs.com, Accessed 17 Nov. 2017. No specific monitoring is required for this medication, but your veterinarian may recommend routine testing depending on your pets' individual needs, other medications they may be on, and/or the issue that initially caused your pet to be placed on this medication. The side effects of Cerenia for dogs is something for dog owners to watch for so to take prompt action should any arise. From time to time, your pup may vomit when at home, too. Cerenia (Maropitant Citrate) tablets are indicated for the prevention of acute vomiting and the prevention of vomiting due to motion sickness in dogs. The following adverse reactions were reported during US studies for the prevention of vomiting due to motion sickness in dogs treated with Cerenia Tablets at a minimum of 8 mg/kg orally one time. Conder GA, Sedlacek HS, Boucher JF, Clemence RG. You can contact Zoetis Inc at 1-888-963-8471. The chemical name is (2S,3S)-2-benzhydryl-N-(5-tert-butyl-2-methoxybenzyl) quinuclidin-3-amine citrate monohydrate. If your dog has been prescribed Cerenia for acute vomiting and continues to vomit or is unable to take the medication because of it, then call your veterinarian right away. If your dog experiences vomiting or diarrhea while taking Cerenia, they may become dehydrated. Cerenia Tablets administered at 40 mg/kg and 50 mg/kg caused clinically relevant signs of weight loss, vomiting, soft stools, weakness, lethargy, salivation and hypokalemia. The side effects of Cerenia for dogs is something for dog owners to watch for so to take prompt action should any arise. How long does it take for cerenia to work? See also My Dog Ate a 300 mg Gabapentin? Before administering Cerenia to your dog, its essential to inform your veterinarian if your dog has any pre-existing medical conditions, allergies, or is currently taking any other medications.
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